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Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

null

《医学前沿（英文）》 2017年第11卷第3期页码 333-339 doi: 10.1007/s11684-017-0564-1

摘要：

Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis (FSGS) accounts for nearly 20% of NS among children and adults. Adult-onset FSGS/NS is often associated with low response to steroid treatment and immunosuppressive medication and poor renal survival. Several genes involved in NS and FSGS have been identified by linkage analysis and next-generation sequencing. Most of these genes encode proteins and are highly expressed in glomerular podocytes, which play crucial roles in slit-diaphragm signaling, regulation of actin cytoskeleton dynamics and maintenance of podocyte integrity, and cell–matrix interactions. In this review, we focus on the recently identified genes in the adult-onset NS and FSGS and discuss clinical significance of screening of these genes.

关键词： nephrotic syndrome focal segmental glomerulosclerosis genetic

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Dynamic response of precast segmental bridge columns under heavy truck impact

《结构与土木工程前沿（英文）》 2023年第17卷第3期页码 327-349 doi: 10.1007/s11709-023-0911-z

摘要： Considering the wide application of precast segmental bridge columns (PSBCs) in engineering practice, impact-resistant performance has gained significant attention. However, few studies have focused on PSBCs subjected to high-energy impacts caused by heavy truck collisions. Therefore, the behavior of PSBCs under a heavy truck impact was investigated in this study using high-fidelity finite element (FE) models. The detailed FE modeling methods of the PSBCs and heavy trucks were validated against experimental tests. The validated modeling methods were employed to simulate collisions between PSBCs and heavy trucks. The simulation results demonstrated that the engine and cargo caused two major peak impact forces during collision. Subsequently, the impact force, failure mode, displacement, and internal force of the PSBCs under heavy truck impacts were scrutinized. An extensive study was performed to assess the influence of the section size, truck weight, impact velocity, and number of precast segments on the impact responses. The truck weight was found to have a minor effect on the engine impact force. Damage was found to be localized at the bottom of the three segments, with the top remaining primarily undamaged. This parametric study demonstrated that larger cross-sections may be a preferred option to protect PSBCs against the impact of heavy trucks.

关键词： precast segmental bridge columns heavy truck collision dynamic response

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Factors affecting the seismic behavior of segmental precast bridge columns

Haitham DAWOOD,Mohamed ELGAWADY,Joshua HEWES

《结构与土木工程前沿（英文）》 2014年第8卷第4期页码 388-398 doi: 10.1007/s11709-014-0264-8

摘要： This manuscript discusses the design parameters that potentially affect the lateral seismic response of segmental precast post-tensioned bridge piers. The piers consist of precast circular cross section segments stacked one on top of the other with concentric tendons passing through ducts made in the segments during casting. The bottommost segments of the piers were encased in steel tubes to enhance ductility and minimize damage. An FE model was used to investigate different design parameters and how they influence the lateral force – displacement response of the piers. Design parameters investigated included the initial post-tensioning stress as a percentage of the tendon yield stress, the applied axial stresses on concrete due to post-tensioning, pier aspect ratios, construction details, steel tube thicknesses, and internal mild steel rebar added as energy dissipaters. Based on the data presented, an initial tendon stress in the range of 40%-60% of its yield stress and initial axial stress on concrete of approximately 20% of the concrete’s characteristic strength is appropriate for most typical designs. These design values will prevent tendon yielding until lateral drift angle reaches approximately 4.5%. Changing the steel tube thickness, height, or a combination of both proved to be an effective parameter that may be used to reach a target performance level at a specific seismic zone.

关键词： finite element analysis concrete precast units bridges

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Self-centring segmental retaining walls—A new construction system for retaining walls

《结构与土木工程前沿（英文）》 2021年第15卷第4期页码 980-1000 doi: 10.1007/s11709-021-0737-5

摘要： This paper reports on an experimental study on a new self-centring retaining wall system. Four post-tensioned segmental retaining walls (PSRWs) were experimentally tested. Each of the walls was constructed using seven T-shaped concrete segments with a dry stack. The walls were tested under incrementally increasing cyclic lateral load. The effect of the wall height, levels of post-tensioning (PT) force, and bonded versus unbonded condition of PT reinforcement on the structural behavior of the PSRWs was investigated. The results showed that such PSRWs are structurally adequate for water retaining structures. According to the results, increasing the wall height decreases initial strength but increases the deformation capacity of the wall. The larger deformation capacity and ductility of PSRW make it a suitable structural system for fluctuating loads or deformation, e.g., seawall. It was also found that increasing the PT force increases the wall’s stiffness; however, reduces its ductility. The residual drift and the extent of damage of the unbonded PSRWs were significantly smaller than those of the bonded ones. Results suggest that this newly developed self-centring retaining wall can be a suitable structural system to retain lateral loads. Due to its unique deformation capacity and self-centring behavior, it can potentially be used for seawall application.

关键词： retaining wall segmental precast concrete unbonded post-tensioning water retaining wall seawall

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Kinetic energy based model assessment and sensitivity analysis of vortex induced vibration of segmental

Nazim Abdul NARIMAN

《结构与土木工程前沿（英文）》 2017年第11卷第4期页码 480-501 doi: 10.1007/s11709-017-0435-5

摘要： In this paper, semi 3D models for segmental Bridge decks are created in ABAQUS CFD program with the support of MATLAB codes to simulate and analyze vortex shedding generated due to wind excitation through considering the stationary position of the deck. Three parameters (wind speed, deck streamlined length and dynamic viscosity of the air) are dedicated to study their effects on the kinetic energy of the system in addition to the shapes and patterns of the vortices. Two benchmarks from the literature Von Karman and Dyrbye and Hansen are considered to validate the vortex shedding aspects for the CFD models. Good agreement between the results of the benchmarks and the semi 3D models has been detected. Latin hypercube experimental method is dedicated to generate the surrogate models for the kinetic energy of the system and the lift forces. Variance based sensitivity analysis is utilized to calculate the main sensitivity indices and the interaction orders for all the three parameters. The kinetic energy approach performed very well in revealing the rational effects and the roles of each parameter in the generation of vortex shedding and predicting vortex induced vibration of the deck.

关键词： vortex induced vibration reynolds number kinetic energy vorticity latin hypercube sampling

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Distinct roles of ASIC3 and TRPV1 receptors in electroacupuncture-induced segmental and systemic analgesia

null

《医学前沿（英文）》 2016年第10卷第4期页码 465-472 doi: 10.1007/s11684-016-0482-7

摘要：

Previous studies have demonstrated the effects of different afferent fibers on electroacupuncture (EA)-induced analgesia. However, contributions of functional receptors expressed on afferent fibers to the EA analgesia remain unclear. This study investigates the roles of acid-sensing ion channel 3 (ASIC3) and transient receptor potential vanilloid 1 (TRPV1) receptors in EA-induced segmental and systemic analgesia. Effects of EA at acupoint ST36 with different intensities on the C-fiber reflex and mechanical and thermal pain thresholds were measured among the ASIC3⁻^/⁻, TRPV1⁻^/⁻, and C57BL/6 mice. Compared with C57BL/6 mice, the ipsilateral inhibition of EA with 0.8 C-fiber threshold (0.8Tc) intensity on C-fiber reflex was markedly reduced in ASIC3⁻^/⁻ mice, whereas the bilateral inhibition of 1.0 and 2.0Tc EA was significantly decreased in TRPV1⁻^/⁻ mice. The segmental increase in pain thresholds induced by 0.3 mA EA was significantly reduced in ASIC3⁻^/⁻ mice, whereas the systemic enhancement of 1.0 mA EA was markedly decreased in TRPV1⁻^/⁻ mice. Thus, segmental analgesia of EA with lower intensity is partially mediated by ASIC3 receptor on Aβ-fiber, whereas systemic analgesia induced by EA with higher intensity is more likely induced by TRPV1 receptor on Ad- and C-fibers.

关键词： electroacupuncture analgesia ASIC3 TRPV1 C-fiber reflex

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Experimental monitoring of the strengthening construction of a segmental box girder bridge and field

Ali Fadhil NASER, Zonglin WANG

《结构与土木工程前沿（英文）》 2012年第6卷第3期页码 308-320 doi: 10.1007/s11709-012-0140-3

摘要： Prestressed concrete segmental box girder bridges are composed of short concrete segments that are either precast or cast in situ and then joined together by longitudinally post-tensioning internal, external, or mixed tendons. The objectives of this study are to monitor the construction process of the external prestressing tendons to strengthen the bridge structure and perform a field load test to measure the strain and the deflection of the anchorage devices of the external prestressing tendons to determine the state of these devices after tension forces are applied. The monitoring process of the external prestressing tendons construction includes inspecting the cracks in the diaphragm anchorage and the deviation block devices before the tension forces are applied to the external tendons; measuring the deformation of the steel deviation cross beam during the tension process; measuring the deformation of the box girder after different levels of tension forces are applied; measuring the elongation of the external tendons in each level of the tension; and measuring the natural frequency of the external tendons after the tension process is complete. The results of the monitoring process show that the measured values of the deformation, the elongation, and the natural frequency meet the requirements. Therefore, there is no damage during the construction and the tensioning of the external prestressing tendons. A field load test is performed to the anchorage beam, the steel deviation block devices, and the steel deviation cross beam. The field load test results of the anchorage devices show that the values of the strains, the stresses, and the deflection are less than the respective allowable limit values in the requirements. Therefore, the anchorage devices have sufficient strength, and the working state is good after the tension forces are applied to the external prestressing tendons.

关键词： prestressed concrete box girder monitoring external tendons strain deflection

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体内-体外混合配束节段预制拼装箱梁足尺模型试验研究

郑开启,卜红旗,刘钊,惠卓,吕志涛

《中国工程科学》 2013年第15卷第8期页码 89-94

摘要：

以南京长江第四大桥引桥为背景，开展了一孔48 m跨径体内-体外混合配束节段预制拼装箱梁的足尺模型试验，以研究该类箱梁在正常使用阶段和施工状态下的结构行为。根据试验箱梁的尺寸参数以及实际约束条件确定了拼装与加载方案。本文重点研究正常使用荷载和梁上运梁两种工况下梁体应力状况与位移变化等结构静力性能，并与试验梁实体有限元模型进行对比分析。研究结果表明：在正常使用阶段，加、卸载后拼装梁体残余变形较小，基本处于弹性工作状态，整体性较好；键齿接缝两侧基本无相对滑移，接缝截面纵向应变沿梁高大致呈线性变化，力学行为基本符合平截面假定；体外预应力束在转向处基本无滑移，体内外预应力增量随跨中弯矩基本呈线性变化；在梁上运梁工况下，实测梁体下缘压应力储备充足，满足运梁安全性要求。

关键词：节段预制拼装模型试验体外预应力足尺试验

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水下盾构法铁路隧道管片衬砌结构的原型加载试验研究

何川,封坤,晏启祥,齐春

《中国工程科学》 2012年第14卷第10期页码 65-72

摘要：

针对我国第一条水下铁路盾构法隧道——狮子洋隧道，采用“多功能盾构隧道结构体试验系统”装置原型管片衬砌结构，在通缝和错缝不同的拼装方式下进行了原型结构加载试验，对其结构力学性能进行深入探讨。试验结果表明，不同水压条件下管片衬砌结构力学特征不同，尤其是当结构开裂后，高水压对于结构内力与形变的发展有明显的减缓作用。狮子洋隧道采用的榫式接头管片结构在通缝与错缝拼装下的破坏特征不同，通缝拼装时结构在高水压条件下纵缝附近区域易发生局部剪切破坏，该研究成果可为同类工程的设计提供有价值的参考。

关键词：水下盾构法铁路隧道管片衬砌结构原型试验榫式接头破坏特征

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Evaluation of the static and dynamic structural performance of segmental pre-stressed concrete box girder

Ali Fadhil NASER, Zonglin WANG

《结构与土木工程前沿（英文）》 2013年第7卷第2期页码 164-177 doi: 10.1007/s11709-013-0196-8

摘要： The objectives of this study are to explain the repairing and strengthening methods which are used to improve the structural performance of the bridge structure, to analyze the static and dynamic responses after strengthening, and to evaluate the performance of the bridge structure after repairing and strengthening. The methods of repairing and strengthening include reconstruction the deck of the bridge by casting 10 cm layer of concrete, strengthening the web and bottom floor of box girders of middle spans and side spans by sticking the steel plates, strengthening the whole bridge structure by using external pre-stressing tendons, and treatment the cracks. The results of theoretical analysis show that the values of tensile stress and vertical deflection are decreased and the compressive stress is increased after strengthening. There are not tensile stresses are appeared in the sections of the bridge structure. The modal analysis results show that the value of natural frequency is equal to 2.09 Hz which is more than the values before strengthening which is equal to 1.64 Hz, indicating that the stiffness of the bridge structure is improved and the strengthening process is effective to improve the cracks resistance and bearing capacity of the bridge structure.

关键词： structural performance steel plates external pre-stressing cracks grouting method static

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用于毫米波焦面阵成像系统的扩展半球介质透镜

孙忠良,窦文斌

《中国工程科学》 2000年第2卷第3期页码 42-47

摘要：

毫米波成像是近年来毫米波领域的一个研究热点，而焦面阵成像因其具有实时成像的优点更加受到重视。文中分析可用于焦面阵成像的扩展半球介质透镜。这种焦面阵成像结构将集成天线阵贴附在透镜背面接收透镜聚焦的功率，消除了集成天线工作在毫米波频段时存在的表面波对天线性能的影响，具有尺寸紧凑、损耗小的特点。采用Stmtton-Chu公式和射线追迹分析了电磁波人射到扩展半球透镜上时在其背面的场分布，即透镜的焦区场分布，以获得透镜用于焦面阵成像时的性能。为验证分析方法的正确性，对平面波垂直人射和会聚高斯束入射两种情形进行了实验验证，实验结果与理论分析吻合较好。该透镜天线还可用来消除常规集成毫米波系统中抛物面天线与集成前端之间的过渡，以降低损耗，改善系统性能，也可用于与准光系统的连接或耦合。该文结果将对上述应用提供理论指导。

关键词：毫米波天线成像扩展半球介质透镜

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预制拼装箱梁现浇横隔梁水化热分析与控制研究

陈扬,钟瑶,郑开启,沈斌,孟少平

《中国工程科学》 2013年第15卷第8期页码 99-103

摘要：

在节段预制拼装桥梁的墩顶节段，常常采用后浇横隔梁的方式来减轻吊装重量。后浇横隔梁在体量上属于大体积混凝土，混凝土水化热问题会引起一些部位拉应力过大，如控制措施不合理，往往会导致预制梁段在施工阶段的开裂。本文结合南京长江第四大桥的引桥工程，基于三维瞬态温度场理论，利用通用有限元程序ANSYS对墩顶梁段现浇块的水化热效应进行了数值仿真，研究箱梁水化热温度场和应力场的分布规律。分析结果表明，水化热引起的箱梁腹板外侧拉应力水平足以导致混凝土开裂，在水化热测试试验中也观测到了箱梁腹板外侧的纵向微裂缝，与分析相符。在研究水化热温度场和应力场分布规律的基础上，进行了控制水化热温度应力的措施研究，在实桥施工中证实是切实有效的。

关键词：混凝土箱梁水化热温度场应力场裂缝